Fig. 1. Experimental procedure and effects of orally administered CJLP55 on atopic dermatitis induced by house dust mite extract.

(a) Experimental procedure for induction of atopic dermatitis and administration of lactobacilli was illustrated. Day zero is defined as the first day of administration of CJLP55 strain. (b) The dermatitis scores were evaluated by observing erythema/hemorrhage, scarring/dryness, excoriation/erosion, and edema. The score was noted once every two weeks until day 56. (c) The photographs were obtained in week eight before the mice were sacrificed. The photographs of NC/Nga mice with Dfb-induced dermatitis were obtained on day 55. (d) The level of total IgE in collected serum on day 28 was determined by ELISA. Data are shown as mean±SD of changes in the dermatitis score and total IgE level of five mice (n=5). ^*p<0.05; ^**p<0.01; ^***p<0.001 compared with control.