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. 2017 Apr 28;12(4):e0175968. doi: 10.1371/journal.pone.0175968

Fig 2. Prolonged treatment with Htt ASO leads to modest reduction in body weight.

Fig 2

Body mass was recorded weekly during IP injections and examined longitudinally using minP-based parametric bootstrap multiple comparison procedure [24][25]. (A) No significant differences were observed between control ASO and saline treated mice (p = 0.58; green); therefore, control ASO and saline treated mice were grouped and compared to Htt ASO treated mice (p < 0.05 after 30 injections; orange) (B) Body mass was reduced by 5% in Htt ASO -treated mice after 30 injections compared to grouped control ASO and saline treated mice (yellow highlighted region; overall curve comparison p = 0.0001).