Fig 6. Hypoactivity and increased anxiety-like phenotypes are not improved by peripheral Htt silencing.

During open field exploration, Htt^Q111/+ mice travel less distance than Htt^+/+ mice (A) and spend more time along the outer walls of the arena (B). This thigmotactic tendency combined with observations that Htt^Q111/+ mice initiate fewer total investigations of both objects during the novel object location task (C) suggest that Htt^Q111/+ mice exhibit anxiety-like phenotypes and are less motivated to explore. However, Htt ASO treatment failed to modulate these phenotypes. ‡ p ≤ 0.05, ‡‡ p ≤ 0.01, ‡‡‡ p ≤ 0.001: by factorial ANOVA.