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. 2016 Aug 18;25(20):4494–4506. doi: 10.1093/hmg/ddw278

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Muscle weakness occurs at earlier ages in FVB Smn^2B/-mice than in BL6 Smn^2B/-mice. (A and B) Analysis of the results from inverted mesh grip tests showing that Smn^2B/-mice had a shorter latency to fall than their control littermates after PND17 in BL6 Smn^2B/-mice (A) and after PND15 in FVB Smn^2B/-mice (B), (two way ANOVA, P < 0.05). There were no significant changes in latency to fall times of Smn^2B/-mice (solid lines) of both strains during the test period (repeated measures ANOVA, P > 0.05). (C and D) Analysis of hind limb suspension test (also known as tube test) revealed that Smn^2B/-mice suspended from their hind limbs had a shorter latency than their control littermates after PND15 in both strains. The latency to fall time of FVB Smn^2B/-mice was significantly shorter at PND11 than earlier ages (D, ≠ on the solid line). In BL6 Smn^2B/-mice the latency to fall time was shorter at PND13 than earlier ages (C, ≠ on the solid line) (repeated measures ANOVA, P <0.05). The goal was set as 60 s for the inverted grip test (A and B), and as 60 s or climbing out of the tube for the tube test (C and D). * indicates significant difference between Smn^2B/-mice and their control littermates.