Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 9;25(20):4369–4375. doi: 10.1093/hmg/ddw267

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 4. — Vitamin B12 treatment partially rescues the Tbx1 haploinsufficiency phenotype. (A) Pharyngeal arch arteries of E10.5 embryos visualised by ink injection. Lateral view of PBS-treated WT (left panel), PBS-treated Tbx1^lacZ/+ (centre), and vitamin B12-treated Tbx1^lacZ/+ (right) embryos. (A’) Graphic representation of the percentage of embryos with 4^th PAA defects (PBS sample n = 21; vitamin B12-treated sample n = 26). (B) Representative immages of aortic arch and great vessels of E17.5 fetuses. (i) WT pattern; (ii) normal pattern in a vitamin B12-treated Tbx1^lacZ/+ fetus; (B’) Examples of aortic arch patterning defects in Tbx1^lacZ/+ fetuses: (i) right aortic arch (RAA), the arrowhead indicates the retropositioned arch; (ii) interrupted arch aortic (IAA) type B, the arrowhead indicates the interruption; (iii) retroesophageal right subclavian artery. Arrows indicate the right subclavian artery. Ao: aorta; lcc: left common carotid artery; rcc: right common carotid artery; rsa: right subclavian artery. (B'') Graphic representation of the percentage of fetuses with aortic arch patterning abnormalities derived from 4^th PAA defects (PBS sample n = 26; vitamin B12-treated sample n = 26).