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. 2016 Aug 15;25(20):4448–4461. doi: 10.1093/hmg/ddw274

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Larger parallel fibre-mediated EPSC amplitude in ET4^-/- mice. (A) Top, representative EPSC waveforms at 6 V stimulus and immunoblot analysis for all genotypes. Bottom, mean PF-PC EPSC amplitudes versus stimulus intensity for 6-week old WT, ET4^-/- and β-III^-/-/ET4^-/- animals. No significant differences detected between ET4^-/- and β-III^-/-/ET4^-/- across the range of stimulus intensities but both significantly different to WT animals using mixed model ANOVA analysis. (B) Top, examples of PF-EPSC waveforms for pairs of stimuli at 6 V. Bottom, degree of paired-pulse facilitation. (C) Single exponential decay time constants. All data are means ± SEM, N = 3–5, n = 11 (β-III^-/-/ET4^-/-), 13 (WT) and 15 (ET4^-/-).