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. 2016 Aug 15;25(20):4448–4461. doi: 10.1093/hmg/ddw274

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Progressive motor impairment in GLAST^-/- mice. (A) Hind limb base width of 6-week and 6-month old animals. (B) Number of hind-limb slips 6-week and 6-month old mice made when crossing narrow, elevated beam. C, Latency of 6-week old animals to fall from rotarod at 3-, 5- and 10-rpm. (D) Latency of 7.5- and 10-month old WT and GLAST^-/- animals to fall from rotarod at 3-rpm. All data are means ± SEM. N = 14 (WT), 14 (young GLAST^-/-), 7 (old GLAST^-/-) in all panels. E, Immunoblot analyses of cerebellar homogenates from 6-week old WT, GLAST^+/- and GLAST^-/- animals.