Figure 5.

Purkinje cell loss in posterior lobules of βIII^-/- mice accelerated by additional early loss of GLAST. (A) Coronal cerebellar sections from 1-year-old WT and βIII^-/- mice immunostained with anti-calbindin antibody. (B) Quantification of Purkinje cell density in 1-year-old WT and βIII^-/- mice. (C) Representative confocal images, from coronal sections, of lobules VIII and IX from 3-month-old mice immunostained with anti-calbindin antibody. (D) Quantification of mean Purkinje cell density in lobules VIII, IX, X and Crus II of hemispheres. All data are means ± SEM, N = 3 for each genotype. Bar, 50 μm.