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. 2017 Apr 17;127(5):1905–1917. doi: 10.1172/JCI89531

Figure 1. CD300f deficiency leads to failure in resolution of colonic inflammation.

Figure 1

(A–D) CD300f+/+ (CD300f WT) or CD300f–/– (CD300f KO) mice were given drinking water containing 2.5% DSS for 7 days, followed by unadulterated water for another 13 days (20 days total). “No DSS” indicates mice without DSS administration. DAI was scored during DSS administration, as described in Methods (A). On day 7 (Inflammation) and day 14 (Resolution), the colon length (B), macroscopic inflammation score (C), and microscopic inflammation score (D) were determined. The pictures in B–D are representative images from the indicated mice; note that CD300f–/– mice have shortened colons with loose stools (B), evident hyperemia (C), and destruction of colonic architecture with elevated cell infiltration (D). Scale bars in H&E staining images: 500 μm. Graphs show data quantification with means; error bars represent SEM (n = 3 in control, n = 15 in day 7, n = 15 in day 14). Two-tailed paired Student’s t test was used to determine statistical significance (*P < 0.05, **P < 0.01, ***P < 0.001).