Table 2.

Multivariate analysis on the effect of prophylaxis on the repeated measures of overall joint ROM over time in 2908 US hemophilia participants aged 2 to 19 years

	Initial ROM status		Rate of ROM change
Covariates	Parameter estimate	P	Parameter estimate	P
Age	−0.85	<.001	—	—
Race: white vs others	1.56	<.001	—	—
Inhibitor: yes vs no	−0.46	.06	—	—
BMI: ≥85th vs <85th percentile	−1.07	.003	−0.09	.001
Primary prophy <4 y: yes vs no	0.96	.24	0.20	.03
Primary prophy 4 or 5 y: yes vs no	0.92	.34	0.10	.29
Secondary prophy: yes vs no	0.54	.46	0.04	.36

Prophy, prophylaxis.