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. 2017 Mar 22;292(17):6882–6894. doi: 10.1074/jbc.M117.778761

Figure 1.

Figure 1.

Myeloid-specific PRMT1 knock-out mice are more susceptible to infection. A and B, relative weight loss (n = 4–6 per group) (A) and survival (n = 14–16 per group) (B) after cecal ligation and puncture (CLP) procedure in wild-type (WT = PRMT1fl/fl) and myeloid-specific PRMT1 knock-out mice littermates (KO = PRMT1fl/fl LysM-Cre/WT). Data are presented as mean ± S.D. *, p < 0.05, **, p < 0.01. C, bacterial load in peritoneum of wild-type or knock-out mice after 24 h of CLP. D, serum cytokine levels 24 h after CLP measured by ELISA. n = 3–5 per group. Data are presented as mean ± S.D. *, p < 0.05. E, wild-type (WT) and myeloid-specific PRMT1 knock-out mice (KO) were injected intraperitoneally with 2 mg/kg of LPS. Serum cytokine levels in control mice were measured at 6 h or 1 h post LPS. Data are presented as mean ± S.D. n = 4–6 per group. *, p < 0.05.