Figure 4.
Establishing the structure-activity relationship of Tg in SPCA1a. A, structure of Tg with the numbering of the carbon atoms and side chains indicated. B, Tg pocket in SERCA1a in the E2 conformation with bound Tg (1IWO (41)) with important residues shown as blue sticks. The same view of the SPCA1a homology model is shown in C, and the residues that are different between SPCA1a and SERCA1a are labeled.