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. Author manuscript; available in PMC: 2017 Sep 20.
Published in final edited form as: Nat Genet. 2017 Mar 20;49(5):730–741. doi: 10.1038/ng.3817

Figure 6. In vivo validation of Wac as a new obligate haploinsufficient gene in prostate cancer.

Figure 6

(a,b) Comparison of anterior prostate lobe tumor weight in 4-month-old mice (a) and 9 month-old (b) mice of the indicated genotypes. In a, n=7 for Pten+/+, n=7 for PtenΔ/Δ, n=9 for PtenΔ/Δ; Wac+/Δ and n=8 for PtenΔ/Δ; WacΔ/Δ. In b, n=3 for Pten+/+, n=7 for PtenΔ/Δ, n=11 for PtenΔ/Δ; Wac+/Δ and n=7 for PtenΔ/Δ; WacΔ/Δ. Boxplots display the 25th to 75th percentiles (boxes), medians (lines), and the 5th to 95th percentiles (whiskers). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, two-tailed Student’s t test. Representative pictures of tumors from 4-month-old mice are shown for each genotype (a). Scale bars, 50 mm for all images.