Table 1. Top fifteen PSB∩PISB CIS genes most highly mutated among the 127 prostate, 26 breast and 125 skin tumors analysed.
Genes are ranked according to the percentage of tumors with insertions in each gene. Chr., chromosome.
| PSB∩PISB CIS genes | Chr. | % of tumors with insertions |
Function or pathway | ||
|---|---|---|---|---|---|
| Total tumors | PSB tumors | PISB tumors | |||
| Prostate | |||||
| Zbtb20 | 16 | 70.1 | 48.9 | 81.7 | Transcription |
| Lpp | 16 | 58.3 | 42.2 | 67.1 | Cell adhesion |
| Celf2 | 2 | 57.5 | 35.6 | 69.5 | Splicing |
| Pard3 | 8 | 55.9 | 37.8 | 65.9 | Cell polarity |
| Arid1b | 17 | 53.5 | 42.2 | 59.8 | Chromatin remodeling |
| Foxp1 | 6 | 51.2 | 31.1 | 62.2 | Transcription |
| Nf1 | 11 | 49.6 | 17.8 | 67.1 | RAS signaling |
| Akap13 | 7 | 45.7 | 37.8 | 50.0 | Small GTPase signaling |
| Etl4 | 2 | 45.7 | 35.6 | 51.2 | Unknown |
| Magi3 | 3 | 39.4 | 26.7 | 46.3 | PI3K/PTEN signaling |
| Nfib | 4 | 38.6 | 35.6 | 40.2 | Transcription |
| Tnrc6b | 15 | 38.6 | 26.7 | 45.1 | PI3K/PTEN signaling |
| Etv6 | 6 | 37.8 | 24.4 | 45.1 | Transcription |
| Trip12 | 1 | 37.0 | 24.4 | 43.9 | Ubiquitin mediated proteolysis |
| Arih1 | 9 | 37.0 | 20.0 | 46.3 | Ubiquitin mediated proteolysis |
| Breast | |||||
| Trps1 | 15 | 96.2 | 91.7 | 100.0 | Transcription |
| Nf1 | 11 | 88.5 | 75.0 | 100.0 | RAS signaling |
| Kansl1 | 11 | 80.8 | 75.0 | 100.0 | Chromatin remodeling |
| Osmr | 15 | 65.4 | 66.7 | 64.3 | Cytokine receptor |
| Tnrc6b | 15 | 65.4 | 50.0 | 78.6 | PI3K/PTEN signaling |
| Arih1 | 9 | 65.4 | 33.3 | 92.9 | Ubiquitin mediated proteolysis |
| Cul3 | 1 | 57.7 | 41.7 | 71.4 | Ubiquitin mediated proteolysis |
| Dyrk1a | 16 | 57.7 | 41.7 | 71.4 | Protein Kinase |
| Pias1 | 9 | 53.8 | 25.0 | 78.6 | Protein sumoylation |
| Ralgapb | 2 | 53.8 | 50.0 | 57.1 | Small GTPase signaling |
| Chd2 | 7 | 50.0 | 33.3 | 64.3 | Chromatin remodeling |
| Uba1 | X | 42.3 | 41.7 | 42.9 | Ubiquitin mediated proteolysis |
| Trp53 | 11 | 34.6 | 25.0 | 42.9 | Tumor suppressor |
| Hspa4 | 11 | 23.1 | 25.0 | 21.4 | Heat shock protein |
| Pcsk7 | 9 | 11.5 | 16.7 | 7.1 | Proteolytic enzyme |
| Skin | |||||
| Chl1 | 6 | 93.6 | 86.0 | 97.6 | Cell adhesion |
| Celf2 | 2 | 76.0 | 65.1 | 81.7 | RNA metabolism |
| Dgkb | 12 | 72.8 | 65.1 | 76.8 | Diacylglycerol kinase |
| Nfib | 4 | 61.6 | 62.8 | 61.0 | Transcription |
| Atxn1 | 13 | 61.6 | 72.1 | 56.1 | Unknown |
| Tcf12 | 9 | 56.8 | 48.8 | 61.0 | Transcription |
| Kmt2c | 5 | 55.2 | 41.9 | 62.2 | Chromatin remodeling |
| Akap13 | 7 | 55.2 | 51.2 | 57.3 | Small GTPase signaling |
| Mbnl1 | 3 | 54.4 | 51.2 | 56.1 | Splicing |
| Arid1b | 17 | 54.4 | 41.9 | 61.0 | Chromatin remodeling |
| Nf1 | 11 | 52.8 | 51.2 | 53.7 | RAS signaling |
| Usp34 | 11 | 52.8 | 46.5 | 56.1 | Ubiquitin mediated proteolysis |
| Zfand3 | 17 | 52.8 | 44.2 | 57.3 | Unknown |
| Fchsd2 | 7 | 52.0 | 44.2 | 56.1 | Unknown |
| Crebbp | 16 | 52.0 | 44.2 | 56.1 | Chromatin remodeling |