Table 2.
Absolute levels of peripheral immune mediators stratified by cohort and case status.
| Peripheral Immune Mediators | Birth Cohort | Newly Diagnosed Cohort | ||
|---|---|---|---|---|
| Patient | Control | Patient | Sibling | |
| (n = 470) | (n = 500) | (n = 460) | (n = 453) | |
| IL-1β | ||||
| Median/Q1–Q3, ng/L | 45.1/22.8–80.0 | 40.3/21.3–77.1 | 23.0/10.3–71.3 | 18.2/8.1–58.9 |
| IL-4 | ||||
| Median/Q1–Q3, ng/L | 20.1/12.4–31.0 | 20.7/12.8–31.7 | 9.5/2.0–21.7 | 8.4/2.0–17.2 |
| IL-6 | ||||
| Median/Q1–Q3, ng/L | 33.7/21.3–60.0 | 37.5/22.1–65.5 | ||
| CXCL8 | ||||
| Median/Q1–Q3, ng/L | 85.2/58.7–138.4 | 89.8/63.7–138.3 | 2517.3/433.5–4914.1 | 1923.5/305.6–4593.0 |
| IL-10 | ||||
| Median/Q1–Q3, ng/L | 242.9/64.5–793.8 | 245.3/72.5–721.2 | 47.2/25.8–92.8 | 44.2/20.9–79.7 |
| IL-12 | ||||
| Median/Q1–Q3, ng/L | 94.8/56.5–147.8 | 92.9/52.5–146.5 | 27.5/12.3–56.1 | 21.7/10.2–45.6 |
| IL-18 | ||||
| Median/Q1–Q3, ng/L | 183.8/119.8–285.9 | 142.4/104.0–212.0 | ||
| IFNγ | ||||
| Median/Q1–Q3, ng/L | 34.7/17.1–61.9 | 39.8/19.8–65.2 | 106.1/57.9–211.3 | 93.9/50.1–177.3 |
| TNFα | ||||
| Median/Q1–Q3, ng/L | 43.7/25.8–67.7 | 42.7/26.1–68.0 | 69.4/26.3–134.8 | 65.0/16.1–131.9 |
| TGFβ | ||||
| Median/Q1–Q3, ng/L | 927.2/603.5–1385.3 | 1006.6/687.7–1414.9 | 233.6/142.6–341.3 | 166.9/104.2–256.4 |
| Leptin | ||||
| Median/Q1–Q3, ng/L | 3079/1953–4678 | 3143/2022–4588 | 368.1/174.5–772.1 | 430.6/192.1–930.7 |
| Adiponectin | ||||
| Median/Q1–Q3, mg/L | 13.4/9.3–20.1 | 13.3/9.1–19.8 | 14.9/11.0–19.5 | 14.4/11.1–19.7 |
| CRP | ||||
| Median/Q1–Q3, mg/L | 0.9/0.3–2.0 | 1.0/0.4–2.0 | 0.04/0.01–0.16 | 0.02/0.01–0.09 |
| MBL | ||||
| Median/Q1–Q3, mg/L | 0.6/0.2–1.0 | 0.5/0.18–1.1 | 1.9/0.7–3.3 | 1.2/0.5–2.3 |
| sTREM-1 | ||||
| Median/Q1–Q3, ng/L | 2868.5/1533.4–4930.9 | 2693.5/1524.9–5180.5 | 3368/244–16411 | 1085/244–9442 |
| CCL2 | ||||
| Median/Q1–Q3, ng/L | 303.3/174.3–725.6 | 261.1/146.1–683.5 | ||
| CCL3 | ||||
| Median/Q1–Q3, ng/L | 234.5/120.4–520.3 | 202.2/107.7–517.7 | ||
| CCL4 | ||||
| Median/Q1–Q3, ng/L | 330.7/187.1–704.5 | 320.1/186.8–739.6 | ||
| CCL5 | ||||
| Median/Q1–Q3, ng/mL | 10.8/6.7–29.2 | 13.7/7.2–36.3 | ||
IL, interleukin; IFNγ, interferon gamma; TNFα, tumor necrosis factor alpha; TGFβ, transforming growth factor beta; CRP, c-reactive protein; MBL, mannose-binding lectin; sTREM-1, soluble triggering receptor expressed on myeloid cells-1, CXCL, chemokine (c-x-c motif) ligand; CCL, chemokine (c-c motif) ligand.