Figure A9.

SIRT1 depletion reverses the increased effect of genistein on cellular proliferation in I/R-induced acute renal injury. Mice were treated as described in supplemental Figure 7. The data were expressed as the mean ± SEM; n = 6; * p < 0.05 vs. Sham; ^# p < 0.05 vs. I/R. (A) Representative photomicrograph of PCNA-stained kidney tissues from the G15 and G15 + Sirtinol groups. Original magnification, 400×; (B) PCNA-positive cells were counted, and the percentage of positive cells is illustrated. The black arrows indicate positive cells.