Figure 10.

The plasma irisin levels in the sedentary mice (Seden) with or without TNBS colitis fed a standard diet (SD) or a high-fat diet (HFD) and subjected or not subjected to voluntary exercise (Volunt). Please note that the plasma irisin concentration was significantly diminished in the sedentary mice fed a HFD and that effect was reversed in the HFD mice subjected to voluntary exercise. Results are mean ± S.E.M. of eight animals per each experimental group. An asterisk indicates a significant change as compared to the respective values in the sedentary mice without colitis fed a SD (p < 0.05, t-test). An asterisk and a cross indicate a significant change as compared to the respective values in the colitis animals fed a SD (p < 0.05, t-test). A cross indicates a significant change as compared to the value obtained in the sedentary animals with colitis fed a HFD without voluntary exercise (p < 0.05, t-test).