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. 2017 Apr 4;127(5):1757–1771. doi: 10.1172/JCI87388

Figure 7. Islet and β cell regeneration in diabetic NOD mice treated with ω-3 PUFAs.

Figure 7

Pancreases were harvested from 9-week-old mice that had received lentivirus treatment and DHA plus EPA dietary intervention. Confocal images (A) and quantification (B) of islets expressing only insulin, without α cells. These islets were discovered next to the ductal epithelium in NOD mice treated with lenti-mfat-1 and fed a DHA plus EPA diet (n = 4/group). β cells (insulin, green), α cells (glucagon, red), and nuclei (DAPI, blue) are shown. Scale bars: 50 μm. *P < 0.05 versus the lenti-con group (ANOVA). Images are representative of 3 biological replicates. All values represent the mean ± SEM.