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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Dermatol Clin. 2017 Jan;35(1):73–84. doi: 10.1016/j.det.2016.07.003

Fig. 2.

Fig. 2

Model of cutaneous SCC macrophage polarization. Th1 and Th2 cells in the microenvironment produce interferon gamma (IFNγ) and IL-4, respectively. These cytokines stimulate M1 classic and M2 alternative phenotypes, resulting in poly activated TAMs. TAMs are characterized by the presence of phosphor-ylated STAT1 and STAT6 and expression of MMP-11, MMP-9, and vascular endothelial growth factor C (VEGF-C).