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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: Sci Transl Med. 2017 Feb 15;9(377):eaaf2584. doi: 10.1126/scitranslmed.aaf2584

Fig. 3. hiPSC-CMs exhibit alterations in intracellular calcium handling after 2 hour treatment with known QT interval-prolonging TKIs.

Fig. 3

(A) Schematic illustrating TKI treatment regimen for hiPSC-CMs before calcium imaging. (B) Raw line scans of individual hiPSC-CM calcium transients following TKI treatment at indicated clinically-relevant concentration and calcium dye treatment over multiple beats. (C) Quantification of hiPSC-CM calcium imaging parameters following 2 hour TKI treatment. N=10 cells recorded for each condition. Data presented as box-and-whisker plots showing the minimum, first quartile, median, mean, third quartile, and maximum of dataset. Student’s t-test indicates significance compared to control (*P<0.05 and **P<0.01).