Table 4.
Gene expression in bone marrow with Modic type 1 (MC1) and type 2 changes (MC2) relative to autologous control bone marrow. Fold-change, confidence interval (CI) and p-values (p) are indicated for all genes analyzed. Significant p-values are in bold. Last column (1vs2) provides p-values for the correlation of MC1 and MC2 for genes with p < 0.1.
| gene | MC1 | MC2 | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| fold change | CI | p | fold change | CI | p | 1vs2 p | |
| BMP2 | 1.05 | 0.74–1.50 | 0.76 | 0.38 | 0.10–1.37 | 0.11 | |
| CCL2 | 1.49 | 0.86–2.61 | 0.14 | 2.30 | 0.65–8.11 | 0.17 | |
| COL1A | 1.94 | 0.97–3.85 | 0.06 | 2.08 | 0.29–15.0 | 0.16 | |
| CSF1 | 0.97 | 0.68–1.37 | 0.84 | 0.90 | 0.41–1.97 | 0.84 | |
| CSF2 | 0.53 | 0.10–2.78 | 0.37 | 1.17 | 0.53–2.57 | 0.62 | |
| CSF3 | 1.12 | 0.30–4.13 | 0.85 | 0.89 | 0.34–2.34 | 0.76 | |
| FGF | 2.36 | 0.02–256 | 0.51 | 3.18 | 0.58–17.5 | 0.12 | |
| GRN | 0.74 | 0.47–1.68 | 0.69 | 0.70 | 0.47–1.05 | 0.02* | |
| IFNG | 0.76 | 0.59–0.97 | 0.05 | 0.58 | 0.08–3.99 | 0.53 | |
| IL12B | 0.92 | 0-Inf | 0.96 | 0.59 | 0.14–2.53 | 0.39 | |
| IL17A | NA | 0-Inf | 0.83 | 0.36 | 0.00–27.0 | 0.20 | |
| IL1A | 1.27 | 0.51–3.14 | 0.55 | 1.53 | 0.47–5.01 | 0.42 | |
| IL1B | 1.00 | 0.72–1.39 | 1.00 | 1.79 | 0.81–3.96 | 0.13 | |
| IL1R2 | 1.10 | 0.30–4.02 | 0.83 | 1.30 | 0.74–2.30 | 0.46 | |
| IL23A | 0.96 | 0.60–1.54 | 0.84 | 0.97 | 0.29–3.20 | 0.95 | |
| IL23R | 1.24 | 0-Inf | 0.88 | 1.25 | 0.19–8.17 | 0.76 | |
| IL4 | 1.05 | 0.66–1.69 | 0.81 | 1.99 | 0.88–4.51 | 0.09 | 0.10 |
| IL6 | 1.27 | 0.93–1.72 | 0.11 | 1.87 | 0.44–7.93 | 0.35 | |
| IL8 | 0.89 | 0.56–1.43 | 0.61 | 1.07 | 0.26–4.38 | 0.91 | |
| MMP13 | 1.63 | 0.06–41.5 | 0.72 | NA | NA | NA | |
| MMP3 | 0.80 | 0.03–19.0 | 0.53 | NA | NA | NA | |
| MMP9 | 1.03 | 0.77–1.37 | 0.85 | 0.20 | 0.04–1.01 | 0.04* | 0.03* |
| MYD88 | 1.12 | 0.69–1.81 | 0.63 | 1.52 | 0.81–2.87 | 0.16 | |
| NFATC1 | 0.99 | 0.69–1.41 | 0.94 | 1.03 | 0.58–1.81 | 0.91 | |
| NFKB1 | 0.48 | 0.13–1.80 | 0.27 | 0.16 | 0.02–1.41 | 0.04* | |
| NGF | NA | NA | NA | NA | NA | NA | |
| OPG | 1.34 | 0.50–3.55 | 0.52 | 1.25 | 0.39–3.98 | 0.67 | |
| OSCAR | 0.73 | 0.35–1.52 | 0.37 | 0.88 | 0.33–2.34 | 0.77 | |
| PPARG | 1.12 | 0.86–1.46 | 0.36 | 1.09 | 0.62–1.94 | 0.73 | |
| RANK | 1.14 | 0.37–3.56 | 0.79 | 1.51 | 0.09–24.0 | 0.70 | |
| RANKL | 1.30 | 0.77–2.20 | 0.30 | 1.21 | 0.36–4.02 | 0.71 | |
| RORC | 1.26 | 0.54–2.96 | 0.55 | 1.56 | 0.62–3.89 | 0.28 | |
| RUNX1 | 1.18 | 0.76–1.84 | 0.42 | 1.17 | 0.68–2.00 | 0.52 | |
| STAT3 | 0.90 | 0.55–1.48 | 0.66 | 0.96 | 0.58–1.58 | 0.85 | |
| TACR1 | 2.41 | 0.44–13.1 | 0.20 | 1.73 | 0.46–6.49 | 0.35 | |
| TGFB1 | 1.01 | 0.64–1.59 | 0.97 | 0.99 | 0.54–1.81 | 0.36 | |
| TLR2 | 1.06 | 0.73–1.54 | 0.73 | 1.69 | 0.81–3.53 | 0.14 | 0.08 |
| TLR4 | 0.84 | 0.51–1.40 | 0.48 | 1.46 | 0.76–2.80 | 0.21 | |
| TLR6 | 0.89 | 0.58–1.36 | 0.56 | 1.36 | 0.68–2.69 | 0.33 | |
| TNF | 0.94 | 0.58–1.50 | 0.76 | 1.57 | 0.65–3.77 | 0.27 | |
| TRAF2 | 0.94 | 0.64–1.38 | 0.74 | 0.81 | 0.55–1.19 | 0.24 | |
| TRAF6 | 1.13 | 0.73–1.76 | 0.54 | 1.04 | 0.57–1.90 | 0.89 | |
| TrkA | 1.13 | 0.60–2.14 | 0.67 | 0.58 | 0.26–1.29 | 0.15 | |
| TrkB | 2.01 | 1.04–3.91 | 0.04* | 2.98 | 1.05–8.50 | 0.04* | |
| TrkC | 1.22 | 0.55–2.70 | 0.59 | 4.33 | 1.07–17.5 | 0.03* | 0.09 |
| VCAM1 | 1.41 | 0.77–2.58 | 0.24 | 0.74 | 0.12–4.39 | 0.71 | |