Figure 1.

BI-ALCL histology. (A) Wright Giemsa staining from a malignant effusion of BI-ALCL demonstrating pleomorphic cells with horseshoe shaped nuclei, nuclear folding and abundant vacuolated cytoplasm (1,000× magnification); (B) immunohistochemistry in tissue section demonstrates sheets of large cells positive for CD30 in a case of BI-ALCL. BI-ALCL, breast implant-associated anaplastic large-cell lymphoma. (Reprinted with permission from Clemens MW, Miranda RN. Coming of Age: Breast Implant-Associated Anaplastic Large Cell Lymphoma After 18 Years of Investigation. Clin Plast Surg 2015;42:605-13.)