Figure 5.

BI-ALCL staging system: this TNM system was modeled after the American Joint Committee on Cancer (AJCC) TNM (tumor, lymph node, metastasis) staging system for solid tumors. T1: lymphoma cells confined to the effusion or a layer on the luminal side of the capsule (IA); T2: lymphoma cells superficially infiltrate the luminal side of the capsule (IB); T3: clusters or sheets of lymphoma cells infiltrate into the thickness of the capsule (IC); and T4: lymphoma cells infiltrating beyond the capsule (IIA), into the adjacent soft tissue or breast parenchyma (III, IV). (×100). (Reprinted with permission from Clemens MW, Medeiros LJ, Butler CE, et al. Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma. J Clin Oncol 2016;34:160-8.)