Figure 6.

Clinical image of a 52-year-old woman who received a cosmetic breast augmentation with textured silicone implants. Twenty years after implantation, she developed swelling of the left breast of recent onset which was aspirated multiple times. (A) Patient then received a partial capsulectomy, implant removal and mastopexy; (B) adequate tumor resection was questionable and despite being asymptomatic, the patient underwent a completion capsulectomy with excision of the posterior capsular wall; postoperative pathology again demonstrated persistent BI-ALCL disease of her chest wall and now with free margins; (C) tissue section demonstrates a nodule with compact tumor cells. Immunohistochemistry demonstrates that most tumor cells (D) which express CD30. Patient received no further adjunctive treatments and is currently 2 years disease free. BI-ALCL, breast implant-associated anaplastic large-cell lymphoma. (Reprinted with permission from Clemens MW, Miranda RN. Coming of Age: Breast Implant-Associated Anaplastic Large Cell Lymphoma After 18 Years of Investigation. Clin Plast Surg 2015;42:605-13.)