Fig. 2.

Histopathological findings in the lung tissue. a Macroscopic examination revealed severe emphysematous lesions (arrowheads) and massive necrotic lesions (bar = 5 cm). b Low-magnification image of a hematoxylin and eosin (HE) stained specimen (bar = 5 mm). In the background of the severely emphysematous lesions, massive infiltration of inflammatory cells and necrosis (arrow) with destruction of the alveoli and vascular walls was observed. c Elastica–Masson staining (bar = 200 μm). Destruction of the vascular walls (arrow) was observed. d High-magnification image of an HE-stained specimen (bar = 50 μm). Massive infiltration of eosinophils and neutrophils was observed. e Grocott staining revealed many filamentous fungi with irregular non-septate hyphae branching at wide angles in the lung lesion (arrow; bar = 50 μm)