Lesion profiles of unusual scrapie cases and controls in brain of clinically affected tg338 mice. Patterns of severity of vacuolation (with se bars) in nine grey matter areas (G1–G9: medulla, cerebellum, superior colliculus, hypothalamus, thalamus, hippocampus, septum, retrosplenial cortex, and cingulate and motor cortex) and three white matter areas (W1–W3: cerebellum, superior cerebral peduncle and basal cerebral peduncle). (a) Classical scrapie 68 × 81, (b) SSBP/1, (c) CH1641, (d) atypical scrapie Scr2, (e) atypical scrapie 51 × 45, (f) L4824, (g) H800, (h) 13 × 85 and (i) vacuolation damage in two individual clinically positive mice inoculated with L4823 [mouse 4 (L4823/4) and mouse 9 (L4823/9)].