Table 1. Avian proteins identified in association with the IBV virion.
UniProt accession no. | Gene name | Protein name | Previously detected in IBV virion* | Detected in SARS-CoV virion† | No. unique peptide matches‡ |
---|---|---|---|---|---|
O73885 | HSPA8 | Heat-shock cognate 71 kDa protein | ✓ | 8, 5, 5 | |
P00356 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | ✓ | 11, 76, 36 | |
P01994 | HBAA | Haemoglobin subunit αA | ✓ | 6, 4, 5 | |
P02001 | HBAD | Haemoglobin subunit αD | 4, 2, 5 | ||
P02457 | COL1A1 | Collagen α1(I) chain | 3, 19, 19 | ||
P02552 | Tubulin α1 chain | 10, 18, 8 | |||
P08251 | ATP1B1 | Sodium/potassium-transporting ATPase subunit β1 | 3, 5, 5 | ||
P08629 | TXN | Thioredoxin | 4, 4, 4 | ||
P08636 | RPS17 | 40S ribosomal protein S17 | ✓ | 5, 6, 2 | |
P09206 | Tubulin β3 chain | ✓ | ✓ | 14, 3, 2 | |
P09244 | Tubulin β7 chain | 16, 8, 3 | |||
P09652 | Tubulin β4 chain | ✓ | 11, 1, 1 | ||
P09654 | VIM | Vimentin | 6, 32, 12 | ||
P0C1H5 | H2B-VII | Histone H2B 7 | ✓ | 12, 2, 2 | |
P0CB50 | PRDX1 | Peroxiredoxin-1 | ✓ | 3, 16, 9 | |
P11501 | HSP90AA1 | Heat-shock protein HSP 90α | ✓ | 13, 11, 4 | |
P14105 | MYH9 | Myosin-9 | 14, 312, 191 | ||
P17785 | ANXA2 | Annexin A2 | ✓ | ✓ | 32, 27, 21 |
P18359 | DSTN | Destrin | ✓ | 3, 21, 12 | |
P24479 | S100A11 | Protein S100-A11 | ✓ | 5, 3, 4 | |
P24797 | ATP1A2 | Sodium/potassium-transporting ATPase subunit α2 | 2, 5, 2 | ||
P41125 | RPL13 | 60S ribosomal protein L13 | 3, 5, 3 | ||
P47836 | RPS4 | 40S ribosomal protein S4 | 5, 20, 7 | ||
P51913 | ENO1 | α-Enolase | ✓ | 7, 12, 7 | |
P68034 | ACTC1 | Actin, α cardiac muscle 1 | 14, 2, 9 | ||
P84247 | H3-IX | Histone H3.3 | 8, 3, 4 | ||
Q5ZJ54 | CCT6 | T-complex protein 1 subunit ζ; | ✓ | 11, 26, 8 | |
Q5ZLC5 | ATP5B | ATP synthase subunit β, mitochondrial | 2, 5, 7 | ||
Q5ZMD1 | YWHAQ | 14-3-3 protein θ | 6, 15, 7 | ||
Q5ZMQ2 | ACTG1 | Actin, cytoplasmic 2 | ✓ | 27, 2, 1 | |
Q5ZMT0 | YWHAE | 14-3-3 protein θ | ✓ | 6, 1, 2 | |
Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | ✓ | 4, 15, 5 | |
Q90705 | EEF2 | Elongation factor 2 | ✓ | 5, 41, 10 | |
Q90835 | EEF1A | Elongation factor 1α1 | ✓ | 8, 44, 18 | |
Q98953 | S100A6 | Protein S100-A6 | ✓ | 4, 3, 3 |
* Proteins previously reported to be associated with the IBV virion by Kong et al. (2010).
† Proteins orthologous to those reported to be associated with the SARS virion by Neuman et al. (2008).
‡ The number of peptide matches in each of the three preparations is shown.