Table 3.
Adjusted ORs (95% CI)1 for metabolic syndrome according to quartile classification of food group intakes by dominant model of APOA1/APOC3 genotypes
| Q1 | Q2 | Q3 | Q4 | P for trend | P for interaction | |
|---|---|---|---|---|---|---|
| APOA1 genotypes (rs670) | ||||||
| Fast foods | 0.08 | |||||
| GG (rs670) (n=383) | 1 (ref.) | 0.7 (0.35–1.56) | 1.20 (0.57–2.44) | 0.6 (0.27–1.22) | 0.32 | |
| GA+AA (rs670) (n=445) | 0.7 (0.31–1.32) | 1.10 (0.55–2.21) | 1.20 (0.57–2.41) | 1.30 (0.60–2.85) | 0.04 | |
| Salty snacks | 0.06 | |||||
| GG (rs670) (n=383) | 1 | 0.41 (0.19–0.87) | 1.40 (0.64–2.85) | 1.04 (0.50–2.16) | 0.51 | |
| GA+AA (rs670) (n=445) | 0.69 (0.33–1.43) | 1.07 (0.52–2.20) | 1.23 (0.60–2.54) | 1.34 (0.66–2.71) | 0.006 | |
| Sugar | 0.02 | |||||
| GG (rs670) (n=383) | 1 | 1.70 (0.87–3.44) | 1.31 (0.64–2.77) | 2.20 (1.02–4.48) | 0.46 | |
| GA+AA (rs670) (n=445) | 3.0 (1.44–6.22) | 1.60 (0.87–3.53) | 1.52 (0.76–3.09) | 1.30 (0.66–2.67) | <0.01 | |
| Nuts | 0.0006 | |||||
| GG (rs670) (n=383) | 1 | 0.87 (0.38–1.64) | 1.31 (0.65–2.63) | 2.40 (1.13–4.91) | 0.01 | |
| GA+AA (rs670) (n=445) | 1.80 (0.86–3.60) | 1.82 (0.93–3.66) | 0.80 (0.30–1.61) | 1.92 (0.96–3.78) | 0.31 | |
| APOA1 genotypes (rs5069) | ||||||
| Fish | 0.04 | |||||
| CC (rs5069) (n=517) | 1 | 1.34 (0.70–2.57) | 1.07 (0.58–1.96) | 0.63 (0.34–1.18) | 0.75 | |
| CT+TT (rs5069) (n=311) | 0.48 (0.23–0.98) | 1.14 (0.58–2.28) | 0.96 (0.46–1.98) | 1.30 (0.64–2.77) | 0.20 | |
| Tea-coffee | 0.007 | |||||
| CC (rs5069) (n=517) | 1 | 0.78 (0.41–1.47) | 0.32 (0.16–0.61) | 0.67 (0.36–1.27) | 0.09 | |
| CT+TT (rs5069) (n=311) | 0.69 (0.34–1.43) | 0.44 (0.21–0.92) | 0.92 (0.42–1.96) | 0.48 (0.24–0.98) | 0.70 | |
| Sugar | 0.04 | |||||
| CC (rs5069) (n=517) | 1 | 1.39 (0.76–2.55) | 1.04 (0.54–2.01) | 1.53 (0.84–2.81) | 0.66 | |
| CT+TT (rs5069) (n=311) | 1.97 (0.94–4.13) | 1.21 (0.59–2.49) | 1.11 (0.55–2.23) | 0.73 (0.36–1.47) | 0.003 | |
| APOC3 genotype (rs5128) | ||||||
| Salty Snacks | 0.15 | |||||
| CC (rs5128) (n=522) | 1 | 0.78 (0.41–1.49) | 1.17 (0.62–2.18) | 1.73 (0.92–3.24) | 0.02 | |
| CG+GG (rs5128) (n=284) | 0.75 (0.36–1.55) | 0.66 (0.32–1.39) | 1.73 (0.82–3.61) | 0.76 (0.34–1.69) | 0.26 |
OR: Odds Ratio, Q: Quartile of food group intakes. APOA1: rs670 (−75G>A), rs5069 (+83C>T), APOC3: rs5128 (3238C>G)
1
ORs (95% CI) were calculated by using conditional logistic regression model, adjusted for baseline BMI and energy intake. Participants were joint classified (8 groups) according to quartiles (Q) of food group intakes and dominant model of rs5128, rs670 and rs5069 genotypes. The lowest quartile of food group intakes and homozygote genotype of major allele were used as the reference group.