Table 4.
Adjusted OR (95% CI)1 for metabolic syndrome and combined APOA1/APOC3 genotypes according to quartile classification of food group intakes
| Q1 | Q2 | Q3 | Q4 | P for trend | P for interaction | |
|---|---|---|---|---|---|---|
| APOA1 (rs670/rs5069) | ||||||
| Sugar | 0.02 | |||||
| GA+AA/CT+TT (n=229) | 1 | 0.44 (0.17–1.16) | 0.36 (0.13–0.99) | 0.23 (0.08–0.64) | 0.001 | |
| Others (n=599) | 0.40 (0.17–0.92) | 0.53 (0.23–1.24) | 0.44 (0.19–1.03) | 0.58 (0.25–1.33) | 0.64 | |
| Fish | 0.03 | |||||
| GA+AA/CT+TT (n=229) | 1 | 2.80 (1.10–6.94) | 2.41 (0.87–6.77) | 4.0 (1.45–10.88) | 0.20 | |
| Others (n=599) | 2.60 (1.15–5.77) | 3.91 (1.64–8.94) | 2.90 (1.26–6.44) | 1.82 (0.78–4.08) | 0.88 | |
| APOA1 (rs670/rs5069)/APOC3 (rs5128) | ||||||
| Sugar | 0.008 | |||||
| GA+AA/CT+TT/CC (n=147) | 1 | 0.24 (0.07–0.87) | 0.26 (0.06–1.02) | 0.14 (0.04–0.52) | 0.001 | |
| Others (n=659) | 0.24 (0.07–0.70) | 0.32 (0.11–0.97) | 0.22 (0.07–0.69) | 0.32 (0.10–0.95) | 0.55 | |
| Fish | 0.01 | |||||
| GA+AA/CT+TT/CC (n=147) | 1 | 3.29 (1.09–9.92) | 2.13 (0.61–7.33) | 6.27 (1.86–21.2) | 0.09 | |
| Others (n=659) | 2.24 (0.87–5.79) | 3.32 (1.28–8.63) | 3.00 (1.16–7.77) | 1.78 (0.68–4.61) | 0.98 | |
| Sweet beverages | 0.03 | |||||
| GA+AA/CT+TT/CC (n=147) | 1 | 4.69 (1.46–15.08) | 7.62 (2.19–26.53) | 9.58 (2.70–33.94) | 0.001 | |
| Others(n=659) | 2.98 (1.17–7.58) | 3.93 (1.51–10.23) | 4.07 (1.62–10.25) | 4.41 (1.72–11.31) | 0.009 | |
APOA1: rs670 (−75G>A), rs5069 (+83C>T), APOC3: rs5128 (3238C>G). DP: Dietary pattern, Q: Quartile of food group intakes.
ORs (95% CI) were calculated using conditional logistic regression model, adjusted for baseline BMI. Participants were joint classified (8 groups) according to quartiles of food group intakes and risk genotype carriers of rs670 (GA+AA) and rs5069 (CT+TT). The lowest quartile of food group intakes and risk genotype carriers were used as the reference group. When APOC3 rs5128 was included in the analysis, the risk genotype combination comprised rs670 (GA+AA), rs5069 (CT+TT) and rs5128 (CC).