. 2017 Apr 27;5:e3254. doi: 10.7717/peerj.3254

Table 1. Controls used in validation of the profile HMM, listing the lantibiotic produced and the subclass of modification protein responsible for lanthionine dehydration for each strain.

Strain	Bacteriocin	Subclass
Lactococcus lactis ssp. lactis S0 ^a^,^b^,^c^,^d	Nisin Z	LanB
Lactococcus lactis ssp. lactis CV56^a^,^b^,^c^,^d	Nisin A	LanB
Lactococcus lactis ssp. lactis IO-1^a^,^b^,^c^,^d	Nisin Z	LanB
Bacillus subtilis subsp. spizizienii ATCC 6633^a^,^b^,^c^,^d	Subtilin	LanB
Staphylococcus aureus subsp. aureus USA300_FPR3757^a^,^c^,^d	Bsa	LanB
Streptococcus mutans CH43^a^,^b^,^d	Mutacin I	LanB
Streptococcus mutans UA787^a^,^b^,^d	Mutacin III	LanB
Streptococcus pyogenes^a^,^b^,^c^,^d	Streptin	LanB
Staphylococcus epidermidis^a^,^b^,^c^,^d	Pep5	LanB
Lactococcus lactis subsp. lactis KF147^c	None	–
Streptococcus mutans GS-5	Mutacin GS-5	LanM
Lactococcus lactis subsp. lactis plasmid pES2	Lacticin 481	LanM
Streptomyces cinnamoneus cinnamoneus DSM 4005	Cinnamycin	LanM
Bacillus paralichenformis APC 1576	Formicin	LanM
Streptococcus salivarius plasmid pSsal-K12	Salivaricin B	LanM
Streptomyces venezuelae ATCC 10712^d	Venezuelin	LanL

Notes.

Lanthionine dehydratase protein identified by our model.

Lanthionine dehydratase protein identified by PF04738 model.

Lanthionine dehydratase protein identified by BlastP.

Lanthionine dehydratase protein identified by BAGEL3.