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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Gen Comp Endocrinol. 2017 Jan 19;247:74–86. doi: 10.1016/j.ygcen.2017.01.019

Table 2.

Representative differentially regulated genes in zebrafish during ovulation that are conserved between zebrafish, human and mouse.

gene symbol (mouse) gene title gene symbol (zebrafish) shared type a log2 Fold Changeb FDR p-value
Inflammatory response and apoptosis
Maf Avian musculoaponeurotic fibrosarcoma (v-maf) AS42oncogene homolog MAF (2 OF 2) T1 3.65 1.52E-14
Pla2g4a Phospholipase A2, group IVA cpla2 T1 3.46 2.43E-17
Azin1 Antizyme inhibitor 1 azin1a T1 3.38 2.77E-14
Runx1 Runt related transcription factor 1 runx1 T1 3.27 2.39E-20
Ptgs2 Prostaglandin endoperoxide synthase 2 ptgs2a T1 3.25 4.30E-08
Zbtb16 Zinc finger and BTB domain containing 16 zbtb16a T1 3.11 9.48E-18
Tnfrsf21 Tumor necrosis factor receptor superfamily, member 21 tnfrsf21 T1 2.66 1.47E-08
Gadd45a Growth arrest and DNA-damage-inducible 45 alpha gadd45ab T1 2.45 7.78E-11
Mcl1 myeloid cell leukemia sequence 1 bcl2l10 T1 2.32 2.35E-08
Litaf LPS-induced TN factor litaf T1 1.63 3.44E-05
Slco2a1 Solute carrier organic anion transporter family, member 2a1 slco2a1 T1 1.62 7.43E-04
Hipk2 Homeodomain interacting protein kinase 2 hipk2 T1 1.28 4.11E-03
Nr1d2 Nuclear receptor subfamily 1, group D, member 2 nr1d2a T2 4.11 9.24E-26
Snai2 Snail family zinc finger 2 snai2 T2 3.43 8.90E-19
Clu Clusterin clu T2 2.90 9.23E-08
Socs3 Suppressor of cytokine signaling 3 socs3a T2 1.42 1.96E-04
Adam8 A disintegrin and metallopeptidase domain 8 adam8b T3 3.55 7.95E-25
Ptger4 Prostaglandin E receptor 4 ptger4b T3 3.13 5.77E-11
Csf1r Colony stimulating factor 1 receptor csf1ra T3 2.92 4.13E-08
Nt5e ecto-5'-nucleotidase nt5e T3 2.37 1.89E-05
Furin Furin furina T3 1.84 1.32E-04
Vascularization
Rgs2 Regulator of G-protein signaling 2 rgs2 T1 7.21 4.08E-86
F3 Coagulation factor III f3a T1 4.86 7.20E-30
Zfand5 Zinc finger, AN1-type domain 5 zfand5a T1 3.12 3.93E-16
Nrp1 Neuropilin 1 nrp1a T1 1.98 9.89E-05
Tfpi2 Tissue factor pathway inhibitor 2 tfpi2 T1 1.71 8.49E-04
Sema3a Semaphorin 3A sema3ab T1 1.15 7.00E-03
F5 Coagulation factor V f5 T2 6.56 4.92E-54
Serpine1 Serine (or cysteine) peptidase inhibitor, clade E, member 1 serpine1 T2 1.84 1.87E-05
Apoe Apolipoprotein E apoea T2 1.67 9.51E-05
Ppap2b Phosphatidic acid phosphatase type 2B ppap2b T3 3.24 2.22E-15
Adipor2 Adiponectin receptor 2 adipor2 T3 2.07 1.37E-06
Cell-matrix adhesion and extracellular matrix remodeling
Tnfaip6 Tumor necrosis factor alpha induced protein 6 tnfaip6 T1 2.25 1.26E-07
Adamts9 A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 9 adamts9 T1 5.91 8.44E-41
Ptx3 Pentraxin 3 ptx3b T1 4.68 3.45E-15
Timp2 Tissue inhibitor of metalloproteinase 2 timp2a T1 3.43 2.34E-21
Rnd3 Rho family GTPase 3 rnd3b T1 2.33 1.68E-07
Ezr Ezrin ezra T1 1.84 1.91E-04
Cd151 CD151 antigen cd151 T1 1.76 5.99E-05
Mkln1 Muskelin 1 mkln1 T2 3.51 7.11E-18
Cldn11 Claudin 11 cldn11a T2 2.19 4.65E-08
Palld Palladin palld T2 2.19 9.19E-07
Thbs4 Thrombospondin 4 thbs4a T2 2.05 3.09E-04
Ctnnd1 Catenin delta 1 ctnnd1 T3 4.20 2.41E-12
Net1 Neuroepithelial cell transforming gene 1 net1 T3 2.79 2.84E-12
Dapk3 Death-associated protein kinase 3 dapk3 T3 2.09 1.49E-09
Lox Lysyl oxidase lox T3 1.92 1.83E-04
Cell cycle
Rgcc Regulator of cell cycle rgcc T1 1.44 1.21E-03
Ccnb2 Cyclin B2 ccnb2 T1 −2.89 4.82E-08
Ccna2 Cyclin A2 ccna2 T1 −2.70 1.00E-07
Mki67 antigen identified by monoclonal antibody Ki 67 mki67 T1 −2.68 9.26E-13
Mcm3 Minichromosome maintenance deficient 3 mcm3l T1 −2.16 1.45E-05
Cdc6 Cell division cycle 6 cdc6 T1 −1.86 1.06E-05
Mcm10 Minichromosome maintenance deficient 10 mcm10 T1 −1.77 5.31E-06
Chek1 Checkpoint kinase 1 chek1 T1 −1.70 2.67E-04
Cdc20 Cell division cycle 20 cdc20 T2 −2.88 2.49E-10
Ccnb1 Cyclin B1 ccnb1 T2 −2.72 5.35E-06
Chek2 Checkpoint kinase 2 chek2 T2 −2.31 2.65E-08
Cdk1 Cyclin-dependent kinase 1 cdk1 T2 −2.29 4.47E-07
Pcna Proliferating cell nuclear antigen pcna T2 −2.12 2.32E-05
Cdk2 Cyclin-dependent kinase 2 cdk2 T2 −1.33 3.34E-03
Mos Moloney sarcoma oncogene mos T3 −2.67 2.48E-08
Hormone receptor
Lhcgr Luteinizing hormone/choriogonadotropin receptor lhcgr T3 1.74 1.19E-04
Esr2 Estrogen receptor beta esr2b T1 −1.39 1.29E-03
a

T1, genes that were regulated similarly among all three species; T2, genes that were regulated similarly only between human and zebrafish; T3, genes that were regulated similarly only between mice and zebrafish.

b

Changes in gene expression were based on log2 fold of the expression in wildtype relative to those in Pgr-KO. Genes were listed by fold change within each shared type in each category.