Table 5.
Associations between ABO Blood Group and ABO allele counts and incident peripheral artery disease by race/ethnicity.a,b,c
| Pooled Race/Ethnicityd | African American | Chinese American | Hispanic American | Non-Hispanic White American | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ABO Blood Type | HR (95% CI) | p-value | Interaction p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value |
| O (Reference) | – | – | 0.30 | – | – | – | – | – | – | – | – |
| A | 1.05 (0.78,1.41) | 0.74 | – | 1.39 (0.86,2.26) | 0.18 | 0.60 (0.15,2.38) | 0.46 | 1.45 (0.74,2.85) | 0.28 | 0.73 (0.46,1.17) | 0.19 |
| B | 1.20 (0.84,1.73) | 0.32 | – | 1.39 (0.81,2.37) | 0.23 | 0.68 (0.20,3.66) | 0.55 | 1.63 (0.59,3.85) | 0.27 | 0.90 (0.44,1.87) | 0.79 |
| AB | 1.08 (0.57,2.08) | 0.81 | – | 1.24 (0.49,3.13) | 0.65 | 0.45 (0.20,2.34) | 0.45 | 4.97 (1.47,16.8) | 0.010 | 0.25 (0.03,1.86) | 0.18 |
|
| |||||||||||
| ABO Allele Count | HR (95% CI) | p-value | Interaction p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value |
| O (Reference) | – | – | 0.44 | – | – | – | – | – | – | – | |
| A | 1.02 (0.81,1.28) | 0.86 | – | 1.16 (0.80,1.68) | 0.43 | 0.77 (0.29,2.08) | 0.61 | 1.38 (0.80,2.40) | 0.25 | 0.81 (0.56,1.17) | 0.27 |
| B | 1.16 (0.87,1.53) | 0.31 | – | 1.20 (0.81,1.78) | 0.36 | 0.67 (0.24,1.87) | 0.45 | 1.93 (1.01,3.67) | 0.045 | 0.84 (0.45,1.56) | 0.59 |
CI, confidence interval; HR, hazard ratio.
a
Incident PAD is defined as ABI ≤ 0.9 at Exam 3 or Exam 5, excluding ABI > 1.4 and prevalent PAD cases.
b
CI = confidence interval; HR = hazard ratio.
c
Adjusted for age, sex, and leading ancestry informative PCs.
d
Pooled analyses adjusted for race/ethnicity using PCs; Interaction tests based on self-reported race/ethicity.