Skip to main content
. 2017 Feb 1;8(14):22490–22500. doi: 10.18632/oncotarget.14989

Figure 4. The ratio of FANCD2-V2 / FANCD2-V1 (mRNA expression) is inversely associated with human tumor stage or grade.

Figure 4

(A) By analyzing the specific exon junction sequence for V1 or V2 from the RNA sequence data set generated from human bladder cancer tissue samples (http://firebrowse.org/), we found the ratio of V2/V1 expression in stage IV tumors was lower than those in lower stag tumors. (B) The V2/V1 ratio in stage IV tumors is significantly lower than that in the combined stage I, II and III tumors. t-test, *p < 0.05. (C) The V2/V1 repression ratio is inversely associated with ovarian tumor stages (r = −0.206, p = 0.004) and grades (r = −0.226, p = 0.0027). Distribution of Wilcoxon scores was based upon two groups of 56 and 134 samples for tumor stage I&II, versus III&IV, respectively, to indicate the correlation between tumor stages and V2/V1 (left panel). Whereas two groups of 71 and 119 samples for tumor grade 1&2, versus 3 respectively were used for the score distribution to show the association between tumor grade and V2/V1 (right panel).