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. 2017 Feb 6;8(14):22524–22533. doi: 10.18632/oncotarget.15121

Figure 4. The distribution of P values for the correlations between each two factors in JAK-STAT pathway in PBMCs of HIV-1-infected subjects on cART.

Figure 4

PBMCs were collected from HIV-1-infected subjects (n = 18) prior to (0 m) or 1 month (1 m), 3 months (3 m), and 6 months (6 m) after cART. Age-matched healthy subjects (n = 18) were set as a control group. Cellular RNAs extracted from PBMCs were subjected to quantitative PCR for the factors in JAK-STAT pathway, including TLRs (TLR-1, TLR-4, TLR-6, TLR-7, TLR-8, TLR-9), IRFs (IRF-3, IRF-7, IRF-9), antiviral factors (OAS-1, MxA, A3G, PKR, ISG-56, Tetherin), inflammatory cytokine (IL-6, IL-10), and adaptor molecular (MyD88, STAT-2). Supplementary Table 1 showed the detailed significances of correlations between each two factors by Spearman. The results in the figure are expressed as the numbers at four significant stages (p < 0.001, p = 0.001~0.01, p = 0.01~0.05, p > 0.05).