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. 2017 Feb 21;8(14):23289–23302. doi: 10.18632/oncotarget.15576

Figure 6. The effects of various tested compounds on cell proliferation.

Figure 6

The two HDAC inhibitors, TSA and SAHA, significantly suppressed cell growth in all three types of HCC cells, HTB-52 (A), HCC HepG2 (B) and liver cells THLE2 (C). The dual HDAC/Notch regulator, VPA, partly suppressed cell growth in all three cell lines as well. One-way ANOVA analysis showed the significant suppressive effects with TSA and SAHA in each cell line, as well with the effective trends in the treatments of VPA among the serial different concentrations. However, the significant effects of the Notch inhibitors DBZ and DAPT were not observed in these cells.