Table 4. Cortical structural changes in femurs and vertebrae of MCP-1−/− and wild-type mice fed the AIN93G or the high-fat diet.
| AIN93GWild-type No LLC | AIN93GWild-type | AIN93GMCP-1−/− | High-fatWild-type | High-fatMCP-1−/− | Diet | p valuesGene | D × G | |
|---|---|---|---|---|---|---|---|---|
| Femurs | ||||||||
| Ct.Ar/Tt.Ar, % | 47.1 ± 0.6 * | 45.4 ± 0.6 | 45.7 ± 0.4 | 44.6 ± 0.5 | 46.5 ± 0.4 | 0.99 | < 0.05 | 0.10 |
| Ct. Th, μm | 165.4 ± 2.2 * | 154.6 2.7 | 153.4 ± 1.9 | 154.7 ± 1.5 | 156.1 ± 3.0 | 0.54 | 0.98 | 0.58 |
| Vertebrae | ||||||||
| Ct.Ar/T.Ar, % | 76.2 ± 0.7 * | 71.8 ± 1.4 | 73.2 ± 0.8 | 72.3 ± 0.9 | 71.5 ± 1.0 | 0.55 | 0.76 | 0.27 |
| Ct.Th, μm | 47.1 ± 0.9 | 42.7 ± 0.9 | 43.6 ± 0.9 | 42.6 ± 0.6 | 43.4 ± 0.6 | 0.86 | 0.29 | 0.93 |
Two-way ANOVA was performed to compare differences among the groups of LLC-bearing mice. A priori contrasts were performed to compare differences between AIN93G-fed wild-type mice with or without Lewis lung carcinoma (LLC);
*p<0.01 compared to AIN93G wild-type. Values are means ± SEM (n = 14-15 per group). Ct.Ar/Tt.Ar: cortical area fraction; Ct.Th: cortical thickness.