Table 2. Genotype and allele distributions of DNMT3A rs1550117 A>G variant in NSCLC patients and normal controls, and their association with the risk of NSCLC.
| rs1550117 A>Gvariant | NSCLCpatients | Normalcontrols | p2 | Logistic Regression | |
|---|---|---|---|---|---|
| Genetic comparison | p2, OR(95% CI)3 | ||||
| G | 1027(85.6%)1 | 1619(81.1%) | 0.001 | G vs. A | 0.001, 1.36(1.18–1.71) |
| A | 173(14.4%) | 377(18.9%) | |||
| GG | 441(73.5%) | 662(66.3%) | 0.001 | GG vs. GA | 0.010, 1.33(1.06–1.71) |
| GA | 145(24.2%) | 295(29.6%) | GG vs. AA | 0.032, 1.95(1.03–3.60) | |
| AA | 14(2.3%) | 41(4.1%) | GA vs. AA | 0.264, 1.45(0.77–2.75) | |
| GG vs. GA+AA | 0.002, 1.39(1.15–1.80) | ||||
| GG+GA vs. AA | 0.058, 1.80(1.00–3.35) | ||||
1 Numbers in parentheses, percentage.
2 The p value was calculated using two-sided χ2 test.
3 Adjusted for age, gender smoking status and alcohol status.