. 2017 Feb 22;8(14):23470–23478. doi: 10.18632/oncotarget.15625

Table 4. Stratification analysis of DNMT3A rs1550117 genotype and allele according to age, gender, smoking status and drinking status in NSCLC patients.

Groups GG		Genotype			Allele		Logistic Regression [p¹, OR(95% CI)]
Groups GG		GG	GA	AA	G	A	G vs. A	GG vs. GA	GG vs. AA	GA vs. AA	GG vs. GA+AA	GG+GA vs. AA
≤ 60 y	NSCLC patients	246	76	8	568	92	0.119, 1.24 (0.95–1.63)	0.062, 1.35 (0.99–1.86)	0.925, 1.04 (0.43–2.56)	0.582, 0.77 (0.31–1.94)	0.073, 1.32 (0.97–1.80)	0.935, 0.96 (0.40–2.35)
≤ 60 y	Normal controls	383	160	13	926	186	0.119, 1.24 (0.95–1.63)	0.062, 1.35 (0.99–1.86)	0.925, 1.04 (0.43–2.56)	0.582, 0.77 (0.31–1.94)	0.073, 1.32 (0.97–1.80)	0.935, 0.96 (0.40–2.35)
> 60 y	NSCLC patients	195	69	6	459	81	0.002, 1.56 (1.17–2.08)	0.074, 1.37 (0.97–1.93)	0.010, 3.26 (1.33–8.03)	0.066, 2.39 (0.94–6.03)	0.013, 1.52 (1.09–2.11)	0.017, 2.98 (1.22–7.28)
> 60 y	Normal controls	279	135	28	693	191	0.002, 1.56 (1.17–2.08)	0.074, 1.37 (0.97–1.93)	0.010, 3.26 (1.33–8.03)	0.066, 2.39 (0.94–6.03)	0.013, 1.52 (1.09–2.11)	0.017, 2.98 (1.22–7.28)
Male	NSCLC patients	312	107	9	731	125	0.003, 1.42 (1.13–1.79)	0.014, 1.41 (1.07–1.85)	0.062, 2.08 (0.96–4.47)	0.336, 1.47 (0.67–3.24)	0.005, 1.46 (1.12–1.90)	0.106, 1.88 (0.86–4.04)
Male	Normal controls	451	218	27	1120	272	0.003, 1.42 (1.13–1.79)	0.014, 1.41 (1.07–1.85)	0.062, 2.08 (0.96–4.47)	0.336, 1.47 (0.67–3.24)	0.005, 1.46 (1.12–1.90)	0.106, 1.88 (0.86–4.04)
Female	NSCLC patients	129	38	5	296	48	0.168, 1.30 (0.90–1.88)	0.347, 1.24 (0.79–1.94)	0.313, 1.71 (0.60–4.86)	0.562, 1.38 (0.46–4.12)	0.233, 1.29 (0.85–1.98)	0.360, 1.62 (0.58–4.59)
Female	Normal controls	211	77	14	499	105	0.168, 1.30 (0.90–1.88)	0.347, 1.24 (0.79–1.94)	0.313, 1.71 (0.60–4.86)	0.562, 1.38 (0.46–4.12)	0.233, 1.29 (0.85–1.98)	0.360, 1.62 (0.58–4.59)
Smoking	NSCLC patients	130	33	4	293	41	0.0003, 2.06 (1.40–3.04)	0.0002, 2.38 (1.50–3.78)	0.142, 2.40 (0.75–7.72)	0.989, 1.00 (0.30–3.39)	0.0001, 2.38 (1.53–3.71)	0.289, 1.88 (0.59–5.99)
Smoking	Normal controls	149	90	11	388	112	0.0003, 2.06 (1.40–3.04)	0.0002, 2.38 (1.50–3.78)	0.142, 2.40 (0.75–7.72)	0.989, 1.00 (0.30–3.39)	0.0001, 2.38 (1.53–3.71)	0.289, 1.88 (0.59–5.99)
Non- smoking	NSCLC patients	313	110	10	736	130	0.090, 1.22 (0.97–1.53)	0.353, 1.14 (0.87–1.49)	0.104, 1.83 (0.88–3.80)	0.215, 1.61 (0.76–3.42)	0.181, 1.20 (0.92–1.55)	0.124, 1.77 (0.86–3.65)
Non- smoking	Normal controls	513	205	30	1231	265	0.090, 1.22 (0.97–1.53)	0.353, 1.14 (0.87–1.49)	0.104, 1.83 (0.88–3.80)	0.215, 1.61 (0.76–3.42)	0.181, 1.20 (0.92–1.55)	0.124, 1.77 (0.86–3.65)
Drinking	NSCLC patients	144	42	6	330	54	0.001, 1.82 (1.29–2.57)	0.008, 1.77 (1.16–2.71)	0.031, 2.80 (1.10–7.12)	0.359, 1.58 (0.60–4.20)	0.002, 1.90 (1.27–2.84)	0.066, 2.39 (0.94–6.02)
Drinking	Normal controls	180	93	21	453	135	0.001, 1.82 (1.29–2.57)	0.008, 1.77 (1.16–2.71)	0.031, 2.80 (1.10–7.12)	0.359, 1.58 (0.60–4.20)	0.002, 1.90 (1.27–2.84)	0.066, 2.39 (0.94–6.02)
Non- drinking	NSCLC patients	297	103	8	697	119	0.109, 1.22 (0.96–1.54)	0.182, 1.21 (0.92–1.60)	0.309, 1.54 (0.67–3.54)	0.577, 1.28 (0.54–2.99)	0.129, 1.23 (0.94–1.61)	0.369, 1.46 (0.64–3.35)
Non- drinking	Normal controls	482	202	20	1166	242	0.109, 1.22 (0.96–1.54)	0.182, 1.21 (0.92–1.60)	0.309, 1.54 (0.67–3.54)	0.577, 1.28 (0.54–2.99)	0.129, 1.23 (0.94–1.61)	0.369, 1.46 (0.64–3.35)

¹The p value was calculated using two-sided χ² test.