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A. iCasp9 is formed by connecting a drug-binding domain, FKBP12-F36V with Δcaspase9 via a SGGGS linker. Binding of small CID (AP1903 or AP20187) leads to dimerization of iCas9, thereby relaying activation signals and initiating mitochondrial apoptosis pathway. B. The bicistronic transgene, iCaps9.2A.ΔCD19, comprises iCasp9 sequence, linked via a short 2A-like sequence, with truncated CD19 using as a selectable marker.
