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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Cancer Res. 2016 Nov 7;77(1):187–197. doi: 10.1158/0008-5472.CAN-16-1267-T

Figure 6. Model of PCDH7-mediated activation of MAPK signaling in lung tumorigenesis.

Figure 6

When overexpressed in lung cancer, PCDH7 interacts with SET and PP2A and facilitates inhibitory PP2A-SET interaction, thereby potentiating MAPK-ERK signaling in cooperation with oncogenic drivers such as KRAS or EGFR (depicted as a receptor tyrosine kinase, RTK).