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. 2017 May 1;8:214. doi: 10.3389/fphar.2017.00214

FIGURE 2.

FIGURE 2

Xanthurenic acid (XA) causes relaxation of isolated mouse mesenteric arteries. (A) Concentration-response curve of XA-induced relaxation of phenylephrine-precontracted mesenteric artery. Values are means + S.E.M. of 6 determinations. (B) Vascular response of phenylephrine-precontracted mouse aorta rings or mesenteric arteries to increasing concentrations of XA (0–1000 μM). Values are means ± S.E.M. of eight determinations. ∗p < 0.05, (Two-way ANOVA + Bonferroni post-test). (C) Comparison of vascular response of phenylephrine-precontracted mouse mesenteric arteries to increasing concentrations of XA (0–1000 μM) or L-kynurenine (0–1000 μM). Values are means ± S.E.M. of six determinations. ∗p < 0.05, (Two-way ANOVA + Bonferroni post-test). (D) Vascular response of phenylephrine-precontracted mouse mesenteric arteries to increasing doses of XA in presence of (1 μM) tetrodotoxin. Values are means ± S.E.M. of 7 determination. (E) Vasorelaxing effect of XA in mesenteric arteries isolated from wild-type (WT) or mGlu2-/- mice. Values are means ± S.E.M. of five determinations.