Skip to main content
. 2017 May 1;8:214. doi: 10.3389/fphar.2017.00214

FIGURE 4.

FIGURE 4

Xanthurenic acid (XA) lowers blood pressure in mice and its serum levels are increased after injection of LPS. (A) Systolic blood pressure (SBP) in C57BL/6 mice treated with vehicle or increasing doses of XA (10, 100 mg/kg). Values are means ± S.E.M. of 10–13 determinations. ∗p < 0.05; (One-way ANOVA + Bonferroni’s Multiple Comparison Test). (B) Serum levels of XA after the i.p. injection of XA (100 mg/kg); ∗p < 0.05 vs. time of XA injection (One-Way ANOVA + Fisher’s LSD). (C) SBP in mice treated with vehicle or LPS (1 mg/kg). Values are means ± S.E.M. of eight determinations. ∗p < 0.05; (Two-way ANOVA + Bonferroni’s Multiple Comparison Test). (D,E) Serum levels of XA and L-kynurenine at different time points after LPS injection. Blood samples were collected at different time points after LPS injection in anesthetized mice. Time 0 = 2 min prior LPS injection. Values are means ± S.E.M. of 3–4 determinations. ∗p < 0.05 vs. time of LPS injection; #p < 0.05 vs. 2 h after LPS; °p < 0.05 vs. 4 h after LPS; x p < 0.05 vs. 24 after LPS (One-way ANOVA + Fisher’s LSD).