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. 2017 May 1;8:482. doi: 10.3389/fimmu.2017.00482

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Copyright © 2017 Wehenkel, Corr, Guy, Edwards, Castellaw, Calabrese, Pagès, Pouysségur, Vogel and McGargill.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DKO^CD4 mice exhibit ectopic accumulation of chondrocytes. Bones were removed from LMC and 129.DKO^CD4 mice, fixed, decalcified, and stained with hematoxylin and eosin (H&E). (A) Sections of spinal column [2× (top) and 10× (bottom)], including a photograph of the paralyzed DKO^CD4 mouse from which they were obtained, are shown. Other sections displayed include the (B) femur [4× and 10× (far right)], (C) sternum (10×), (D) vertebra (4×), and (E) sphenoid bone (2×). (F) H&E analysis of bones is depicted from 4-week-old 129.DKO^CD4 mice, showing femur (4×), sphenoid bone (2×), sternum (10×), and vertebra (4×). Images are representative of at least five mice.