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. 2017 May 1;10:112. doi: 10.3389/fnmol.2017.00112

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Copyright © 2017 Mendoza and Scharff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FoxP1/2/4 can hetero-dimerize in the brain. The three panels depict representative co-immunoprecipitation experiments from nuclear protein extracts of adult zebra finch brains with anti-FoxP2 (A,C), anti-FoxP4 (B), or nonspecific IgG (A–C) under non-denaturing conditions. Proteins were resolved by SDS-PAGE, transferred to nitrocellulose, and analyzed by sequential immunoblotting with anti-FoxP1 (A-left and B-right, Westerns), or anti-FoxP2 (A,C left Westerns), or anti FoxP4 (B,C right panels). In all cases, a hetero-dimer was co-immunoprecipitated with the specific antibodies from whole forebrain lysate and no signal of the same size was detected in the IgG control, suggesting an interaction of FoxP proteins.