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. 2017 May 1;10:117. doi: 10.3389/fnmol.2017.00117

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Copyright © 2017 Gomis-Perez, Soldovieri, Malo, Ambrosino, Taglialatela, Areso and Villarroel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of apocalmodulin regulation of Kv7 PI(4,5)P₂ efficacy. Illustration of the proposed equilibrium between three functional Kv7 channels pools. The PI(4,5)P₂ efficacy depends upon the abundance of apoCaM and subunit composition. Pool 1 and pool 3 represent the currents observed after expression of a CaM sponge or overexpression of CaM₁₂₃₄, respectively.