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Effect of reduced calmodulin levels on Kv7.2 current density. (A) Representative current traces measured in response to the indicated voltage protocol in cells expressing Kv7.2 or Kv7.2 + neurogranin (sponge, green). (B) Comparison of the effect on current density of endogenous CaM (gray) and reduced CaM levels (+Sponge, Green). (C) The V1/2 (mV) under reduced and resting CaM conditions were (number of experiments in brackets): −27.8 ± 0.9 (8) and −15.6 ± 2.1 (8).
