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. 2017 May 1;10:117. doi: 10.3389/fnmol.2017.00117

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Copyright © 2017 Gomis-Perez, Soldovieri, Malo, Ambrosino, Taglialatela, Areso and Villarroel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of acute reduction of PI(4,5)P₂ levels on calmodulin-dependent regulation of Kv7.2 current density. (A) Scheme of the voltage protocol used to illustrate current inhibition quantification. (B) Averaged current reduction after activation of DrVSP at +100 or +120 mV under resting conditions (gray symbols) and with CaM₁₂₃₄ (blue symbols). (C) Averaged current reduction in the presence of the CaM sponge (green symbols). (D) Comparison of current density with CaM₁₂₃₄ (blue) and the CaM-sponge (green) in cells co-expressing PIP5K (purple). (E) Averaged current reduction after activation of DrVSP in the presence PIP5K in control and cells co-expressing CaM₁₂₃₄ or the CaM-sponge (magenta lines).