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. 2017 May 1;10:117. doi: 10.3389/fnmol.2017.00117

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Copyright © 2017 Gomis-Perez, Soldovieri, Malo, Ambrosino, Taglialatela, Areso and Villarroel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The F24A mutation results in larger current density and increased resistance to acute PI(4,5)P₂ depletion independently of CaM elevation. (A) Averaged current density of Kv7.2 channels (gray column), F24A mutation under resting conditions (orange) and co-expressing CaM₁₂₃₄ (blue). (B) Top, cartoon of a channel subunit. Bottom, sensitivity of the F24A mutant to DrVSP activation under resting conditions (orange), and with co-expression of CaM₁₂₃₄ (blue). The reference effect on wt Kv7.2 is plotted in gray color.