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. 2017 May 1;10:117. doi: 10.3389/fnmol.2017.00117

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Copyright © 2017 Gomis-Perez, Soldovieri, Malo, Ambrosino, Taglialatela, Areso and Villarroel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of alterations of calmodulin levels on Kv7.2/3 current density. (A) Comparison of the effect on current density of CaM₁₂₃₄ (blue) and the CaM-sponge (green). (B) Activation voltage-dependency measured under reduced (green), resting (gray) and elevated (blue, CaM₁₂₃₄) CaM levels. The V_1/2 (mV) under low, resting and elevated CaM conditions were (number of experiments in brackets): −26.5 ± 2.0 (7), −30.5 ± 1.2 (9), and −34.1 ± 1.7 (6).