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. 2017 May 1;10:117. doi: 10.3389/fnmol.2017.00117

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Copyright © 2017 Gomis-Perez, Soldovieri, Malo, Ambrosino, Taglialatela, Areso and Villarroel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of alterations of PI(4,5)P₂ levels on calmodulin-dependent regulation of Kv7.2/3 current density. (A) Comparison of the effect on current density of CaM₁₂₃₄ (blue) and the CaM-sponge (green) in cells co-expressing PIP5K (purple). (B) Averaged current reduction after activation of DrVSP at different voltages in resting conditions (gray symbols) and with CaM₁₂₃₄ (blue symbols). (C) Averaged current reduction after activation of DrVSP in resting conditions (gray symbols) and with a CaM sponge (green symbols).